In the present study, AME significantly enhanced the rate of wound contraction
and epithelization period.
The ointment containing 5% (w/v) of the EA fraction showed an increased wound contraction
rate compared to the one of the negative control group (e.g., on the 8th day, we observed a wound healing of 94.48% for mice treated with 5% EA against 84.92% for the control group) (Table 2).
Validation of Wound Contraction
. In our experiment, the amount of wound recovery that occurred in a given period was determined using the H3 model, and the contraction and depth transformation were performed using the methods proposed in this paper.
Simoes et al., "Mast cell concentration and skin wound contraction
in rats treated with Brazilian pepper essential oil (Schinus terebinthifolius Raddi)," Acta Cirurgica Brasileira, vol.
However, on 16th postwounding day, Group I animals have 92.02% wound contraction
(which may be due to self-immunity of the animals), whereas in Groups II and III animals exhibit 93.43 and 93.29% effect by Soframycin and CCP, respectively.
This is demonstrated by a significant increase in the rate of wound contraction
and by enhanced epithelization, an increase in skin-breaking strength and an increase in hydroxyproline content, which is a reflection of increased collagen levels.
The percentage of wound contraction
in untreated and treated groups was measured on 7th, 14th, 21st, 08th post wound day and the results are shown in table 4.
Application of the photo-cross-linkable chitosan hydrogel on full-thickness skin incisions made on the backs of mice significantly induced wound contraction
and accelerated wound closure and healing compared with the untreated controls (24-26).
usually occurs approximately one week after healing and the new scar is still weak.
Percentage of wound contraction
was calculated by using the following formula.
This growth factor causes wound contraction