In the present study, AME significantly enhanced the rate of
wound contraction and epithelization period.
The ointment containing 5% (w/v) of the EA fraction showed an increased
wound contraction rate compared to the one of the negative control group (e.g., on the 8th day, we observed a wound healing of 94.48% for mice treated with 5% EA against 84.92% for the control group) (Table 2).
Validation of
Wound Contraction. In our experiment, the amount of wound recovery that occurred in a given period was determined using the H3 model, and the contraction and depth transformation were performed using the methods proposed in this paper.
Simoes et al., "Mast cell concentration and skin
wound contraction in rats treated with Brazilian pepper essential oil (Schinus terebinthifolius Raddi)," Acta Cirurgica Brasileira, vol.
However, on 16th postwounding day, Group I animals have 92.02%
wound contraction (which may be due to self-immunity of the animals), whereas in Groups II and III animals exhibit 93.43 and 93.29% effect by Soframycin and CCP, respectively.
This is demonstrated by a significant increase in the rate of
wound contraction and by enhanced epithelization, an increase in skin-breaking strength and an increase in hydroxyproline content, which is a reflection of increased collagen levels.
The percentage of
wound contraction in untreated and treated groups was measured on 7th, 14th, 21st, 08th post wound day and the results are shown in table 4.
Application of the photo-cross-linkable chitosan hydrogel on full-thickness skin incisions made on the backs of mice significantly induced
wound contraction and accelerated wound closure and healing compared with the untreated controls (24-26).
Wound contraction usually occurs approximately one week after healing and the new scar is still weak.
Percentage of
wound contraction was calculated by using the following formula.
This growth factor causes
wound contraction and closure.