Cycle

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Cycle

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Acer's pipeline includes three clinical-stage candidates: ACER-001 (a fully taste-masked, immediate release formulation of sodium phenylbutyrate) for the treatment of various inborn errors of metabolism, including urea cycle disorders (UCDs) and Maple Syrup Urine Disease (MSUD); osanetant for the treatment of various neuroendocrine disorders and EDSIVO (celiprolol) for the treatment of vascular Ehlers-Danlos syndrome (vEDS) in patients with a confirmed type III collagen (COL3A1) mutation.
Recent research on ruminant showed that NCG can improve urea cycle in gut tissue [11] and increased plasma ARG concentration, balanced amino acid profile; thereby efficiently improve dairy production and protein when used in high producing cows [12].
found improvement of minimal hepatic encephalopathy in cirrhosis after zinc supplementation.21 Therefore, it can be proposed that zinc supplementation may reduce hepatic encephalopathy by improving the effectiveness of the urea cycle.
Clinical manifestations and growth of patients with urea cycle disorders in Japan.
Urea cycle. The enzymes and transport proteins involved in the urea cycle are illustrated in boxes with a red outline.
One possibility is that ammonia accumulated in hepatocytes is initially transported by regulating ammonia transport-related proteins AQP8 and RHCG in mitochondria, which impairs the structure and function of mitochondria via opening mPTP and the intrinsic apoptotic pathway, thus causing energy metabolic disorders and oxidative damage, which affect the urea cycle [41-43].
After many doctor visits, lots of tests, and months of fear, a Metabolic Specialist diagnosed me with a rare genetic defect, arginase deficiency, a part of the urea cycle group of birth defects.
By mid-2017, Synlogic plans to initiate a Phase 1 healthy volunteers study for its lead candidate, SYNB1020, which is for the potential treatment of Urea Cycle Disorders and hepatic encephalopathy, both diseases where patients experience elevated ammonia levels.
By mid-2017, Synlogic plans to initiate a Phase 1 healthy volunteers study for its lead candidate, SYNB1020, which is for the potential treatment of Urea Cycle Disorders (UCD) and hepatic encephalopathy (HE), both diseases where patients experience elevated ammonia levels.
Carglumic acid is a key therapeutic tool in the management of rare, life threatening inborn metabolic disorders affecting the urea cycle; as such it was a natural candidate for the Company's products portfolio.
Previously asymptomatic heterozygous OTC-deficient women can present when faced with catabolic stressors, and biochemical profiling is consistent with impaired urea cycle function.
Gandolfo et al., "Sodium phenylbutyrate decreases plasma branched-chain amino acids in patients with urea cycle disorders," Molecular Genetics and Metabolism, vol.