Ghassemi Toussi, "Resolution of wide complex tachycardia after administration of hypertonic sodium bicarbonate in a patient with severe tricyclic antidepressant
poisoning," Resuscitation, vol.
Toxicology reviews: Targeted management strategies for cardiovascular toxicity from tricyclic antidepressant
overdose: The pivotal role for alkalinization and sodium loading.
Initially, a statistically significant association was found between the REM-sleep related narcoleptic symptoms and the tricyclic antidepressant
medication status of the NIQ respondents.
also have direct cardiotoxic effects, due to inhibition of [Na.sup.+], [Ca.sup.2+], and K+ channels, and can induce delayed cardiac conduction (2).
After a diagnosis of depression, pharmacologic treatment options include tricyclic antidepressants
and selective serotonin reuptake inhibitors.
, serotonin-norepinephrine reuptake inhibitors (SNRIs), anticonvulsants, and mexilefine have all been studied, with the most consistent positive trial data seen for tricyclic antidepressants
In a follow-up study in 2006 by McGill University, Toronto, researchers from the same research group failed to find significant evidence of the increased risk, but nonetheless saw differences between the two groups of tricyclic antidepressants
, with the group of drugs originally suspected of carcinogenicity numerically associated with higher breast cancer risk.
Forty patients were on a tricyclic antidepressant
; the others were roughly evenly divided between mirtazapine, reboxetine, venlafaxine, quetiapine, and SSRIs.
We first addressed this issue in a study that compared neurodevelopmental measures in the preschool children of 80 women who had taken a tricyclic antidepressant
during pregnancy, 55 women who had taken fluoxetine, and 84 women who had not taken any drug known to have adverse fetal effects.
About half the patients who do not respond to an initial trial of either a selective serotonin reuptake inhibitor (SSRI) or a tricyclic antidepressant
will respond to some degree when switched to a medication from the other class.
Of 400 women and 235 men diagnosed with chronic major depression or double depression, 57% of the women responded to the selective serotonin reuptake inhibitor sertraline (Zoloft) by 12 weeks; 46% responded to the tricyclic antidepressant
The tricyclic antidepressant
clomipramine passes into breast milk in greater quantities.