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Interstitial lung abnormalities were associated with both a decrease in total lung capacity and a lesser amount of emphysema.
Pulmonary Functions: Mean values of total lung capacity (TLC), forced vital capacity (FVC) forced residual capacity (FRC), residual volume (RV) and RV/ TLC were normal or near normal (Table I).
Excised lungs of rats killed immediately after inhalation were inflated to 3.5 kPa corresponding to total lung capacity and air dried.
FVC = forced vital capacity; FEV1 = forced expiratory volume in 1 s; TLC = total lung capacity; RV = residual volume; DLco = diffusing capacity of the lung for carbon monoxide; Sp[O.sub.2] = arterial oxygen saturation measured by pulse oximetry; A-aD[O.sub.2] = alveolar-arterial oxygen difference; ANA = antinuclear antibody; KL-6 = Krebs von den Lungen- 6; SP = surfactant protein; GAP = (gender (G), age (A), and two lung physiology variables (P) (FVC and DLco)).
In the present study, restrictive or obstructive patterns were defined when the total lung capacity (TLC) or the forced expiratory volume in 1 s/forced vital capacity (FE[V.sub.1]/FVC) were below the lower limit of normality.
[11] Lung inflation to near total lung capacity is a major physiological stimulus for release of surfactant and prostaglandins into the alveolar spaces.
A total lung capacity <80% of the predicted value for a patient's age, race, sex and height defines the restrictive pathophysiology.
Pulmonary function test revealed significant restriction: forced vital capacity (FVC): 1.17 liters, 36% of predicted, forced expiratory volume in 1st second (FEV1): 0.98 liters, 40% of predicted, (FEV1/FVC) 84, total lung capacity (TLC): 58% of predicted, and diffusion lung capacity for carbon monoxide (DLCO) being significantly reduced, at 53% of predicted.
Pulmonary function testing was performed in accordance with the American Thoracic Society and European Respiratory Society standards and included the following parameters: Percent of predicted normal forced vital capacity (FVC%Pred), percent of predicted normal forced expiratory volume in 1 s (FEV1%Pred), FEV1/FVC%Pred ratio, percent of predicted normal total lung capacity (TLC%Pred), and percent of predicted normal diffusing capacity of the lung for carbon monoxide (DLCO%Pred).
The child then takes a full, deep inspiration, aiming for total lung capacity (TLC), and then immediately gives a maximal 'blast' of expiration and a full exhalation, i.e.
This approach has the advantage of graphically displaying the time course of change in all of the relevant operating lung volumes throughout exercise relative to total lung capacity (TLC).
Eric Jaeger Master Lab pulmonary function equipment was used to measure the forced vital capacity (FVC), forced expiratory volume in one second (FEV1), forced expiratory flow 25-75% (FEF25-75), total lung capacity (TLC), residual volume (RV) and diffusion capacity for carbon monoxide (DLCO).

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