This study investigated the permeation of Mn [sup]2+ delivered via
topical administration as a contrast agent for an MRI.
Evaluation of the mydriatic effects of
topical administration of rocuronium bromide in Hispaniolan Amazon parrots (Amazona ventralis).
15) To justify the
topical administration of tranexamic acid, an important question is whether fibrinolysis occurs at the aqueous or vascular side of the clot.
Studies assessing
topical administration of nalbuphine have not been carried out in rabbits, animals largely used in ophthalmic research.
In the event that stridor does not respond to appropriately placed
topical administration of local anaesthesia, other causes such as vocal cord paralysis or oedema should be considered and measures should be taken to further secure the airway by endotracheal intubation, if needed.
The study further demonstrated that the combination of oral and
topical administration of lutein/ zeaxanthin provided even more powerful improvements, increasing skin hydration by 60%, skin elasticity by 20% and the amount of superficial lipids present in the skin by 50% after adjustment for placebo, all while decreasing the oxidation of those beneficial lipids by 64%.
Topical administration of the extract inhibited nystatin-induced edema proportionally to the doses used, and this effect at a dose of 4.
Topical administration permits very little drug to be absorbed and so the risk from topical application is miniscule.
Local delivery of an siRNA to the eye via intravitreal injection or
topical administration is aimed at controlling the proliferation of abnormal blood vessels associated with one form of age-related macular degeneration.
In addition, Isis has four compounds in human clinical trials: ISIS 2302, an inhibitor of ICAM-1, is in a pivotal quality trial for Crohn's disease, Phase II clinical trials for renal transplant rejection and is being explored as an enema formulation for ulcerative colitis, a
topical administration for psoriasis and an aerosol administration for asthma.
4] It is interesting to note that the other cases of topically induced toxicity all involved treatment for varicella,[2,5-9] and most, as in this case, combined oral and
topical administration of the drug.
Ziarco's pipeline includes a histamine H4 receptor antagonist programme, with a lead compound that has completed a Phase 1 multiple ascending dose study; a clinical stage cytosolic phosholipase A2 (cPLA2) inhibitor; histamine H3 receptor antagonists possessing CNS-sparing properties, with a lead compound in advanced preclinical development; as well as early-stage spleen tyrosine kinase (SYK) inhibitor molecules suitable for
topical administration.
