[1, 2] Fusion could be defined as a conjunction of two separated tooth germs
and identify as radiographically two separate pulp chambers and root canals.
Expression of beta-catenin in human tooth germ
A panoramic radiograph taken a year ago showed the presence of tooth germs
of the permanent maxillary canines in a favourable position with no overlapping of the crowns over the roots of teeth 12 and 22 (Figure 8).
In addition, Fgf7 transcripts have been detected in the developing bone surrounding the tooth germ
Trauma, such as fracture of the alveolar process, may also contribute to hypodontia, though disruption of tooth germ
development, although evidence supporting this is weak in the literature.
The development of halved tooth germs
. A study in experimental embryology.
Dental anomalies occur during the embryological and developmental life of the tooth and usually involve a single tooth germ
. Some consider gemination as division of single tooth germ
by invagination and subsequent development of two teeth, whereas fusion occurs when two separated tooth germs
Ameloblasts within the developing tooth germ
are very sensitive to external stimuli, and many factors can result in enamel abnormalities.
The phylogenetic theory as a regression to the anthropoids whose dentition had more teeth, the autonomic recessive inheritance or linkage to the x chromosome, an abnormal reaction to a local traumatic episode, environ mental factors, dichotomy of the tooth germ
, and the theory of hyperactivity of the dental lamina are the most accepted ones .
The second method for tooth regeneration is to isolate and transplant stem cells to establish epithelial-mesenchymal interactions and reconstruct the tooth germ
. Five major sources of stem cells have been proposed: dental pulp stem cells (DPSCs); stem cells from human exfoliated teeth (SHEDs); periodontal ligament stem cells (PDLSCs); stem cells from the apical root papilla (SCAPs); dental follicle stem cells (DFSCs) (Table 2, Figure 2).
1038) that connation was "linked to the origin of a supernumerary tooth based on a similar mechanism," specifically early developmental division of the tooth germ
. Stein (1962) also reported connate premolars in the European mole.
A new function of BMP-4: dual role for BMP-4 regulation of sonic hedgehog expression in the mouse tooth germ