Effect of tidal volume
, sampling duration, and cardiac contractility on pulse pressure and stroke volume variation during positive-pressure ventilation.
Respective effects of high airway pressure, high tidal volume
, and positive end-expiratory pressure," American Review of Respiratory Disease, vol.
Friedman, "Mechanical ventilation with high tidal volume
induces inflammation in patients without lung disease," Critical Care, vol.
From the pathophysiological point of view, the ventilation-associated injury will depend on the stress and tension to which the lung parenchyma is subjected as a result of tidal volume
, respiratory rate, flow, inspiration time, PEEP, volume and recruitment manoeuvres.
These included blood pressure (BP) and heart rate (HR) by continuous electrocardiogram and BP monitoring, Fi[O.sub.2], PEEP, compliance, resistance, peak inspiratory pressure, respiratory rate (total breaths per minute (b/min) and spontaneous b/min), spontaneous minute volume, expiratory tidal volume
and actual minute volume.
In a small retrospective study conducted in 12 patients with both subarachnoid hemorrhage and ARDS, a lung protective strategy (i.e., tidal volume
of 5-8 ml/kg and PEEP of 10-15 cm [H.sub.2]O) was employed with resulting hypercapnia (pC[O.sub.2] of 50-60 mm Hg; Petridis et al., 2010).
Burtx et al., "A trial of intraoperative low tidal volume
ventilation in abdominal surgery," The New England journal of medicine, vol.
During NPPV tidal volume
, respiratory rate, airway pressures, leakage, and spontaneous breathing activity were continuously measured and recorded every 10 s using commercial software (VentView 2.0, Drager Medical Ag & Co, Lubeck, Germany).
Despite over 100 clinical trials of both supportive therapies and biological agents, the only unequivocally effective intervention over the last two decades has been the use of low tidal volume
As with the PEEP device, the relationship between exhaled tidal volume
, exhaled peak airflow, and pressure in the Sham device was measured with a lung simulator for 50 breaths.
There are two main components of breathing: tidal volume
and lung capacity.
Initially, participants were mechanically ventilated in the volume-induced mode, with a tidal volume
of 8 ml per kilogram of body weight, inspiratory flow of 60 litres per minute (square wave), with hyperinflated cuff, positioned in a supine 30-degree head-up position, and underwent tracheal aspiration.