Severe hypothyroidism in patients dependent on prolonged thyroxine
infusion through a jejunostomy.
JOHN Lazarus, an emeritus professor in clinical endocrinology, said: "An underactive thyroid, which is in the neck, doesn't produce the hormone thyroxine
, which is essential for the metabolism.
O'Reilly reports that from the 1940s through the 1960s, the average quantity of thyroxine
prescribed was 200 to 300 micrograms daily.
Major Finding: Among 36 pregnancies, 14 subjects needed no additional thyroxine
to maintain adequate suppression; 22 needed dosage increases and, of those, 4 were still not adequately suppressed during the entire pregnancy.
Low free thyroxine
also correlated with retinopathy of prematurity severity, and with worse color vision and contrast sensitivity upon visual evoked potential testing at 6 months, reported Ms.
Reduced levels of thyroxine
can produce tiredness, weight gain, hair loss, constipation, dry flaky skin and, rarely, heart problems.
Patients may well worry about suddenly finding their "frusemide" has turned into "furosemide" and they may wonder whether the "levothyroxine" is the same as the "thyroxine
" they had last time.
In a study of more than 3,000 adults age 65 and older who were followed for more than 12 years, those with normal levels of free thyroxine
(also referred to as T4) and thyroid-stimulating hormone (TSH) levels of 10 micro units per liter (mU/L) or above--which indicates subclinical hypothyroidism--had twice the risk of developing heart failure compared to those with normal thyroid levels.
Treatment of a goiter with thyroxine
has questionable positive value and puts the patient at considerable risk for the problems of hyperthyroidism such as cardiac dysrhythmias and especially osteoporosis.
If your T4 blood test is low, you have an underactive thyroid and you're probably taking oral thyroxine
Treatment of hypothyroidism involves thyroxine
therapy (Eutroxsig, Oroxine).
Treatment for hypothyroidism is relatively straightforward--supplemental thyroid hormone, typically thyroxine
. Treatment for hyperthyroidism can be more complex, however, depending on the cause and severity of the disease, age and other medical conditions.