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Statistical composite that measures changes in the economy or in financial markets, often expressed in percentage changes from a base year or from the previous month. Indexes measure the ups and downs of stock, bond, and some commodities markets, in terms of market prices and weighting of companies in the index.


A statistical measure of the value of a certain portfolio of securities. The portfolio may be for a certain class of security, a certain industry, or may include the most important securities in a given market, among other options. The value of an index increases when the aggregate value of the underlying securities increases, and decreases when the aggregate value decreases. An index may track stocks, bonds, mutual funds, and any other security or investment vehicle, including other indices. An index's value may be weighted; for example, securities with higher prices or greater market capitalization may affect the index's value more than others. One of the most prominent examples of an index is the Dow Jones Industrial Average, which is weighted for price and tracks 30 stocks important in American markets.


The relative value of a variable in comparison with itself on a different date. Many security price indicators such as the Standard & Poor's series and the New York Stock Exchange series are constructed as indexes. Also called stock index. See also base period.


To adjust a variable by a selected measure of relative value. For example, it has been proposed that an investor's basis on a security be indexed for changes in consumer prices so that only real increases in value will be taxed. Also called tax indexing. See also subindex.


An index reports changes up or down, usually expressed as points and as a percentage, in a specific financial market, in a number of related markets, or in an economy as a whole.

Each index -- and there are a large number of them -- measures the market or economy it tracks from a specific starting point. That point might be as recent as the previous day or many years in the past.

For those reasons, indexes are often used as performance benchmarks against which to measure the return of investments that resemble those tracked by the index.

A market index may be calculated arithmetically or geometrically. That's one reason two indexes tracking similar markets may report different results. Further, some indexes are weighted and others are not.

Weighting means giving more significance to some elements in the index than to others. For example, a market capitalization weighted index is more influenced by price changes in the stock of its largest companies than by price changes in the stock of its smaller companies.


(1) A statistical indicator that measures changes in the economy in general or in particular areas.An example is the cost-of-living index.(2) A reference point against which measurements are taken for purposes of making future adjustments.An adjustable-rate mortgage might begin with an interest rate of 6 percent and provide that it will increase or decrease in a like percentage as the increase or decrease between today's quoted price for 10-year U.S.Treasury bonds and the price on the loan's annual anniversary date.We would say that 10-year T-bonds are the index.

Some leading loan indices include

• Wall Street Journal prime
• Federal discount rate
• Fed funds rate
• 11th District Cost of Funds
• 10-year Treasuries
• One-year LIBOR

References in periodicals archive ?
Table 1: Computed safety indices for LTE Parameter Computed Value Therapeutic Index 1.
Although no new agents have replaced warfarin as the standard oral anticoagulant, its narrow therapeutic index is shifting through the use of less intense regimens.
Therefore, the "no adverse effect level," or "NOAEL," was determined to be greater than or equal to 300 mg/kg and the therapeutic index was determined to exceed 100-fold.
The ones we're worried about are the ones with a narrow therapeutic index, such as digoxin.
These novel LNPs exhibit significant improvements in potency and broadened therapeutic index for RNAi therapeutics, as evidenced by our recent human data with ALN-PCS, and also define Alnylam's LNP platform for advancement of ALN-TTR02 and potentially other 'Alnylam 5x15' programs.
Research projects to establish the therapeutic index of anticancer cytotoxic drugs are one of the key factors responsible for expected growth.
The many, distinct advantages of using human GrB over conventional toxins are lower systemic toxicity and, therefore, a greater therapeutic index compared to other targeted therapeutic agents, and impressive biological activity without release of GrB from the antibody.
Furthermore targeted delivery of chemotherapeutic agents into tumor cell will improve their therapeutic index and hereby limits their side effects as well as the associated pain.
Some drugs have a wide therapeutic index and only reach toxic levels at doses higher than those that have any kind of therapeutic value, while other drugs may have a very narrow therapeutic index or a therapeutic index where toxicity occurs simultaneously with therapy, as in the case of agents used in chemotherapy regimens.
However, other drugs may have a very narrow therapeutic index or a therapeutic index where toxicity occurs simultaneously with therapy, as in the case of chemotherapeutic agents.
IMS will continue to support and market its existing medical and promotional services worldwide, including the company's National Disease and Therapeutic Index (NDTI) and Integrated Promotional Services (IPS) offerings in the U.
While our state-of-the-art agonist IS-Abs are being tested in the clinic, a parallel SME-driven effort will aim at the development of 2nd generation agonist IS-Abs with superior therapeutic index.

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