The fibroblast-like
synovial cell in rheumatoid arthritis: a key player in inflammation andjoint destruction.
On the other hand, the reported high levels and activity of ACE in monocytes and
synovial cells of RA patients seem to be concordant with the high frequency of the homozygous ACE deletion in RA patients.
Paleolog, "Hypoxia upregulates angiogenesis and
synovial cell migration in rheumatoid arthritis," Arthritis Research and Therapy, vol.
Microscopically the lesion has papillary protrusions with a membrane of
synovial cells covering mature adipose tissue with or without hyperaemic capillaries (3, 5).
(3) Through this stimulation, proliferation of the
synovial cells occurs and the production of inflammatory mediators and enzymes causes cartilage destruction, ultimately leading to the formation of a "pannus" (granulation tissue), which covers the articular surface.3 Growth delay is a common feature, obvious in Robert's case because he was approximately 150cm in height.
Fukuda, "Isolation and characterization of
synovial cells from the human temporomandibular joint," Journal of Oral Pathology and Medicine, vol.
However, the influence of
synovial cells or FLSs-mediated formation and deposition of calcium minerals have not been examined to date.
Furthermore, Treg may slow down the progression of RA by regulating apoptosis of
synovial cells and T lymphocytes [4,5].
Lindberg et al., "Salmonella lipopolysaccharide in
synovial cells from patients with reactive arthritis," The Lancet, vol.
In the present study, we found that thapsigargin, a wellknown inhibitor of ER calcium-ATPase, may inhibit the cell proliferation of MH7A human rheumatoid arthritis
synovial cells in a time- and dose-dependent manner.
suggested synovial origin with micro-infarction of
synovial cells after inflammation and ischaemia, (1) whereas Popert et al.
The majority of these cysts are lined with
synovial cells and contain a straw-coloured fluid.