The fibroblast-like synovial cell
in rheumatoid arthritis: a key player in inflammation andjoint destruction.
On the other hand, the reported high levels and activity of ACE in monocytes and synovial cells
of RA patients seem to be concordant with the high frequency of the homozygous ACE deletion in RA patients.
Paleolog, "Hypoxia upregulates angiogenesis and synovial cell
migration in rheumatoid arthritis," Arthritis Research and Therapy, vol.
Microscopically the lesion has papillary protrusions with a membrane of synovial cells
covering mature adipose tissue with or without hyperaemic capillaries (3, 5).
(3) Through this stimulation, proliferation of the synovial cells
occurs and the production of inflammatory mediators and enzymes causes cartilage destruction, ultimately leading to the formation of a "pannus" (granulation tissue), which covers the articular surface.3 Growth delay is a common feature, obvious in Robert's case because he was approximately 150cm in height.
Fukuda, "Isolation and characterization of synovial cells
from the human temporomandibular joint," Journal of Oral Pathology and Medicine, vol.
However, the influence of synovial cells
or FLSs-mediated formation and deposition of calcium minerals have not been examined to date.
Furthermore, Treg may slow down the progression of RA by regulating apoptosis of synovial cells
and T lymphocytes [4,5].
Lindberg et al., "Salmonella lipopolysaccharide in synovial cells
from patients with reactive arthritis," The Lancet, vol.
In the present study, we found that thapsigargin, a wellknown inhibitor of ER calcium-ATPase, may inhibit the cell proliferation of MH7A human rheumatoid arthritis synovial cells
in a time- and dose-dependent manner.
suggested synovial origin with micro-infarction of synovial cells
after inflammation and ischaemia, (1) whereas Popert et al.
The majority of these cysts are lined with synovial cells
and contain a straw-coloured fluid.