Comparison of misoprostol plasma concentrations following buccal and sublingual administration
Adverse events commonly observed with the sublingual administration
of buprenorphine/naloxone sublingual tablets during clinical trials and post-marketing experience are headache, nausea, vomiting, hyperhidrosis, constipation, signs and symptoms of withdrawal, insomnia, pain and peripheral edema.
Higher complication rates have been reported for oral and sublingual administration
A common practice among American allergists is off-label sublingual administration
of mixtures of eight or more pollen extracts.
You can do sublingual administration
at home and it's safe.
Therefore, though during experimentation we lack resources but our permeation results depicted that sublingual administration
of frovatriptan can result in double of its bioavailability, which can be proven clinically and is the matter of future research.
The 20-mg/kg BPA dose was selected based on pharmacokinetic data from a preliminary experiment in order to obtain plasma concentrations of unconjugated BPA of the same order as those observed after sublingual administration
of BPA at the TDI dose level.