(21) stated that high ammonia levels may have detrimental effects on
stellate cell function.
Generation of hepatic
stellate cells from human pluripotent stem cells enables in vitro modeling of liver fibrosis.
In the normal pancreas, connective tissue, resident fibroblasts (PFs), pancreatic
stellate cells (PSCs), immune cells, and vascular cells play a critical role in tissue repair and wound healing (Figure 2(a)).
Zhanget al., "Activation ofPPAR[gamma]/P53 signaling is required for curcumin to induce hepatic
stellate cell senescence," Cell Death & Disease, vol.
van Grunsven, "Epigenetic regulation of hepatic
stellate cell activation and liver fibrosis," Expert Review of Gastroenterology & Hepatology, vol.
Crosas-Molist et al., "NADPH oxidase NOX4 mediates
stellate cell activation and hepatocyte cell death during liver fibrosis development," PLoS One, vol.
The latter was paucicellular formed by small, bland, spindle to
stellate cells having indistinct cytoplasmic margins and hyperchromatic nuclei (Figure 1(b)).
Hepatic
stellate cells (HSCs) play an important role as a central component in the fibrosis process induced by alcohol consumption.
To investigate the biochemical aspects of HSC activation, we performed a comparative proteomic analysis of normal and activated rat HSCs (A-HSCs), (6) which led to the discovery of "
stellate cell activation-associated protein" (STAP) (1) [later renamed cytoglobin (CYGB) (7)].
StellaTUM: current consensus and discussion on pancreatic
stellate cell research.
Curcumin targets multiple pathways to halt hepatic
stellate cell Activation: updated mechanisms in vitro and in vivo.
Hepatic
stellate cell line modulates lipogenic transcription factors.