(21) stated that high ammonia levels may have detrimental effects on stellate cell
Generation of hepatic stellate cells
from human pluripotent stem cells enables in vitro modeling of liver fibrosis.
In the normal pancreas, connective tissue, resident fibroblasts (PFs), pancreatic stellate cells
(PSCs), immune cells, and vascular cells play a critical role in tissue repair and wound healing (Figure 2(a)).
Zhanget al., "Activation ofPPAR[gamma]/P53 signaling is required for curcumin to induce hepatic stellate cell
senescence," Cell Death & Disease, vol.
van Grunsven, "Epigenetic regulation of hepatic stellate cell
activation and liver fibrosis," Expert Review of Gastroenterology & Hepatology, vol.
Crosas-Molist et al., "NADPH oxidase NOX4 mediates stellate cell
activation and hepatocyte cell death during liver fibrosis development," PLoS One, vol.
The latter was paucicellular formed by small, bland, spindle to stellate cells
having indistinct cytoplasmic margins and hyperchromatic nuclei (Figure 1(b)).
Hepatic stellate cells
(HSCs) play an important role as a central component in the fibrosis process induced by alcohol consumption.
To investigate the biochemical aspects of HSC activation, we performed a comparative proteomic analysis of normal and activated rat HSCs (A-HSCs), (6) which led to the discovery of "stellate cell
activation-associated protein" (STAP) (1) [later renamed cytoglobin (CYGB) (7)].
StellaTUM: current consensus and discussion on pancreatic stellate cell
Curcumin targets multiple pathways to halt hepatic stellate cell
Activation: updated mechanisms in vitro and in vivo.
Hepatic stellate cell
line modulates lipogenic transcription factors.