In order to investigate possible causes of infection and/or neutropenia abdominal ultrasonography was performed and revealed splenomegaly
Clinical features like splenomegaly
were commonly present in CML; hepatomegaly was evenly distributed; lymphadenopathy was seen mostly in CLL.
We emphasize that in case of different multisystemic findings, such as ichthyosis, hearing loss, hepatomegaly, splenomegaly
, cirrhosis, cataract, keratopathy, myopathy, and mental retardation, physicians should suspect Chanarin Dorfman syndrome.
Five (32.5%) patients had constitutional symptoms at the time of presentation and 4 (25%) had massive splenomegaly
. The median WBC count was 36x109/l, haemoglobin level was 8.2 g/dl while the platelet count was 296x109/l.
Overall, patients who have CNS symptoms and extensive white-matter abnormality in cranial MRI, combined with mildly decreased blood cells and splenomegaly
during fever should be observed closely.
CDC contacted the 10 states with the highest number of patients with splenomegaly
, as well as Georgia, because of its geographic proximity to CDC.
The most consistent symptoms were hepatomegaly (8/35) and splenomegaly
There was angular chelosis, splenomegaly
was found upto 6cm below left subcostal margin along its axis.
The most common clinical findings include fever, splenomegaly
, and anemia.
was associated with poor health and poor athletic ability in the ancient Roman, Egyptian and Babylonian eras.
A diagnosis of HLH requires either a molecular diagnosis consistent with HLH or the fulfillment of five of the following eight clinical, laboratory, and histopathological criteria: fever; splenomegaly
; cytopaenia affecting at least two of three cell lineages in the peripheral blood; hypertriglyceridaemia and/or hypofibrinogenaemia; haemophagocytosis in the bone marrow, spleen, or lymph nodes; low or absent natural killer cell activity; hyperferritinaemia; and high levels of soluble-IL-2 receptor (Table).3,6