Otorhinolaryngologic examination showed a 3.8 cm x 2.5 cm growth right pyriform sinus (PFS), biopsy from which revealed pleomorphic spindle cell
tumor with large hyperchromatic nuclei, prominent nucleoli with frequent mitosis with a mitotic rate of 4 per high-power-field arranged in intersecting fascicles.
The fine needle aspiration biopsy of the mass showed spindle cell
Histologically, GISTs are classified as spindle cell
tumors (70%), epithelioid cell tumors (20%), and mixed-type tumors, which are rarely observed.
Microscopically, GIST can show either spindle cell
morphology or epithelioid cell morphology.
Histopathologic examination showed hyperplasia of spindle cells
with tendency toward the pulmonary inflammatory myofibroblastic tumor (IMT) [Figure 1]f1 and [Figure 1]f2.
Cutaneous spindle cell
lesions encompass a heterogeneous group of tumors that range from reactive to benign, borderline, and malignant tumors.
MSP should be considered in the differential diagnosis of tumours with spindle cell
Poorly differentiated spindle cell
neoplasms pose a diagnostic challenge to histopathologists because of a lack of specific morphologic features on standard histopathology.
The spindle cell
variant was included within the embryonal category along with botryoid and anaplastic variants.
Holler et al., "Differential diagnosis of laryngeal spindle cell
carcinoma and inflammatory myofibroblastic tumor--Report of two cases with similar morphology," Diagnostic Pathology, vol.
Authors have emphasized that the most common diagnostic difficulty arises with other benign and malignant spindle cell
tumors (including spindle cell
carcinomas and sarcomas) and fibromatosis .
It has multiple subtypes, out of which monophasic (spindle cell
carcinoma) has close histological resemblance to other tumors including fibrosarcoma, leiomyosarcoma, and spindle cell
variant of squamous cell carcinoma that are relatively more common.