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Osteopontin is an autoantigen of the somatostatin cells in human islets: identification by screening random peptide libraries with sera of patients with insulin-dependent diabetes mellitus.
An important mediator named somatostatin inhibits gastric acid, also inhibits immune reactive somatostatin cells. [2] In patients with duodenal ulcer, amount of somatostatin peptide present in gastric antral mucosa are reduced (McHenry Jr et al 1993).
(1993) and Grimelius e Wilander (1980), endocrine cells are argyrophillic or argentaffin, with the exception of insulin immunoreactive, cholecystokinin and somatostatin cells, which are not labeled by silver (POLAK et al., 1993).