In a paper published on May 9, the Thomson Lab highlights a better way to grow smooth muscle cells
, one of the two cellular building blocks of arteries, from pluripotent stem cells.
Panettieri Jr, "Noncontractile functions of airway smooth muscle cells
in asthma," Annual Review of Physiology, vol.
For immunohistochemical analysis, 4 mm transversal sections were processed with monoclonal antibodies specific to anti-PCNA (Proliferating Cell Nuclear Antigen) (1:200, Dako Cytomation, Inc.) to identify the cells in the S-phase indicating proliferation; anti-actin specific antibodies were used to identify smooth muscle cells
(dilution 1: 100) and anti-CD68 to identify macrophages.
Studies on the subject refer to the interaction between endothelial cells in the arterial wall and vascular smooth muscle cells
playing an important role in ensuring vascular integrity.
The possible role of hydrogen sulfide as a smooth muscle cell
proliferation inhibitor in rat cultured cells.
Zargham, "Tannin extracted from sumac inhibits vascular smooth muscle cell
migration," McGill Journal of Medicine, vol.
Merenick et al., "Phosphorylation of GATA-6 is required for vascular smooth muscle cell
differentiation after mTORC1 inhibition," Science Signaling, vol.
The phenomenon of decreased contractile response of vascular smooth muscle cells
to TP receptor agonist U46619 was also seen in streptozotocin-induced diabetic rats .
Mulberry leaf extract inhibits vascular smooth muscle cell
migration involving a block of small GTPase and Akt/NF-kappaB signals.
[sup] Different studies showed that increased proliferation and migration of vascular smooth muscle cells
(VSMCs), which caused by influences of stimulatory cytokines and disturbances of intracellular pH (pH [sub]i ), are critical events in the pathophysiology of atherosclerosis and restenosis.
The researchers conducted their experiments on smooth muscle cells
that they genetically engineered.
Vascular smooth muscle cells
(SMCs) are involved in lesion progression, which is responsible for the pathogenesis resulting from atherosclerosis .