The same forces were applied to the atoms of K209 side chain
in a structure with R209K substitution.
Because the side chain
of salmeterol is anchored at the exosite, the active head portion continually attaches to and detaches from the receptor site.
The cycloaliphatic epoxy resin was mixed with different amounts of the copolymer having a fluorinated side chain
. An accelerator was added at 3 phr for the total amounts of the epoxy resin and copolymer.
In other words, the largest tensile strength of the blends increased as the side chain
content of compatibilizers increased.
We speculated that the unique three-dimensional shape of the lipophilic side chain
may play an important role in allosteric activation of the channels through hydrophobic interactions.
There is evidence that the beneficial effect of MK-4 on bone health may be due more to its side chain
than to its vitamin K activity, which might explain why pharmacological doses appear to be necessary to achieve the observed effect.
Reduced testosterone levels were accompanied by the decreased expression of StAR (steroidogenic acute regulatory protein) and 3[beta]-HSD (3[beta]-hydroxysteroid dehydrogenase), as well as increased levels of P450scc (cytochrome P450 side chain
cleavage), in Leydig cells.
The principal component of HybridSil materials is the thermally stable, flexible polyorganosiloxane macromolecule, which provides a polymeric scaffold that may be chemically modified with side chain
moieties and main chain copolymer segments for demanding high-temperature environments greater than 350 C.
However, a glutamate (E) paired with an aspartate (D) will still give a player 2 points (the only difference between these two amino acids is a methenyl group (CH2) in the side chain
Tocotrienols isoprenoid side chain
has three double bonds as compared to tocopherol's saturated side chain
Recent developments include (1) an optimization method for side chain
identification and fitting based on the Nelder-Meade Simplex algorithm; (2) identification of noncrystallographic symmetry through pattern recognition in real-space (that is, electron density), which can be used to improve phases; and (3) the use of selenium sites from seleno-methionine MAD experiments to enhance side chain
building and sequence alignment through identification of methionine residues.
A comprehensive review of the evidence shows that the attributable risk of a cross-reactive allergic reaction varies and is strongest when the chemical side chain
of the specific cephalosporin is similar to that of penicillin or amoxicillin.