It turned out that mistakes occur most commonly in the ribosome
However, if a ribosome
starts translating this sentence one letter too late, the sentence would read:
The findings show that total ribosome
levels work in combination with certain structural elements of messenger RNA to determine the direction of a stem cell's development and differentiation.
The results, (http://www.mcponline.org/content/16/2/243) published in the journal Molecular and Cellular Proteomics Monday, found that when fewer calories were consumed, ribosomes
, the part of the cell responsible for making protein, slowed down.
profiling data reveals that uORFs can exist in an out-of-frame relative to the main coding sequence .
Solithromycin's activity against resistant strains is driven by its ability to interact with three sites on the bacterial ribosome
, compared to one for current macrolides.
Induction of apoptosis by ribosome
inactivating proteins: importance of N-glycosidase activity.
Known as the cells protein "factory," the ribosome
"translates" what are called "amino acids"-think of phrases in a sentence-into proteins that play vital functions in the human body, from twitching the muscles and sending out signals to digesting food and providing structure for hair and bone.
Polypeptides are synthesized on particles called ribosomes
. Synthesis begins with the formation of a 30S ribosomal subunit + charged tRNA + mRNA complex which recruits a 50S subunit to complete the mature 70S ribosome
Amino glycosides inhibit protein synthesis by binding to the 30S subunit of the mycobacterium ribosome
. The majority of mutations that confer amino glycoside resistance lead directly or indirectly to alterations in the amino glycoside binding pockets of the ribosome
, which prevent drug binding but preserve ribosome
function as occurs with mutations in the rpsL, rrs, and gidB genes.
Ada Yonath, 75, won the 2009 Nobel Prize in chemistry and is to the study of the ribosome
what Rosalind Franklin was to DNA.