Hepcidin is a hormone produced only in hepatocytes and is involved in iron release by reticuloendothelial
macrophages and iron absorption from the intestinal epithelium [8, 30].
Many studies have found iron deposition in the liver,[sup],,,, and in both hepatocytes and reticuloendothelial
cells.[sup],, Di Bisceglie et al .[sup] were the first to find elevated serum ferritin and iron levels in patients with chronic hepatitis (both chronic hepatitis B and CHC).
[18.] Dubose DA, McCreary J, Sowders L, Goode L (1983) Relationship between rat heat stress mortality and alterations in reticuloendothelial
carbon clearance function.
In further study in NAFLD, apoptosis-specific M30 CK-18 correlated with reticuloendothelial
system (RES) cell iron in the liver and nonalcoholic steatohepatitis .
The low iron levels in overweight and obese subjects are most probably caused by the inflammatory mechanisms, which arrest iron in the reticuloendothelial
system by releasing different inflammatory mediators like cytokines and so forth [21, 22].
Histoplasma capsulatum mainly infects the lungs and passes asymptomatically to involve the skin and reticuloendothelial
in adults, because the functions of the spleen are assumed by other reticuloendothelial
organs (Traub et al, 1987).
The primary source of bilirubin is the daily release of hemoglobin from the breakdown of RBCs in the reticuloendothelial
In the current study, carbon particle clearance test was used as an indicator of phagocytic activity of reticuloendothelial
system measured by clearance of carbon particles from blood stream (Neha and Mishra, 2011).
indomethacin, valproate, phenytoin, penicillin) Autoimmune neutropenia Nutritional deficiencies Bone marrow infiltration Reticuloendothelial
sequestration Table 2.
Among all these magnetic nanoparticles, magnetite (Fe3O4) nanoparticlesarethe most promising for magnetic hyperthermia because magnetite has all those characteristics which are required for biomedical applications such as biocompatibility, non-toxicity, superparamagnetism, water-dispersible, ability to leave reticuloendothelial
system (RES) and easy preparation.
Hepcidin blocks the iron transporter responsible for the release of iron from cells of the reticuloendothelial