Threshold

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Threshold

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(6) However, the level of glucosuria does not typically rise in tandem because the capacity of the kidney to reabsorb glucose (ie, Tm glucose) is increased in diabetes, resulting in an increased renal threshold for glucose excretion (~200 to 250 mg/dL).
Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects.
The occurrence of glycosuria is known to be a result of plasma glucose concentrations in excess of the renal threshold for glucose and is, therefore, indicative of the magnitude of hyperglycemia.