A G[alpha]s protein-coupled membrane receptor
, distinct from the classical oestrogen receptor
, transduces rapid effects from oestradiol on [[[Ca.
The company is using its large portfolio of patented G protein-coupled receptor
targets to design improved drugs and to map biological pathways that may offer new ways to treat diseases.
For their part, Lummen and his Bayer colleagues are studying whether flubendiamide interacts with any of three mammalian ryanodine receptors
Benzoate X receptors
[alpha] and [beta] are pharmacologically distinct and do not function as xenobiotic receptors
Predix, based in Lexington, MA, is a pharmaceutical company focused on the discovery and development of novel, highly selective, small-molecule drugs that target G-Protein Coupled Receptors
(GPCRs) and ion channels.
also binds to the androgen receptor
with high affinity and non-competitively with respect to free androgen (Martin et al.
Because many flavonoids activate the estrogen receptor
(ER), it is possible that inhibitory ER-AhR crosstalk that has previously been reported (Jeong and Lee 1998; Ricci et al.
CCX915 is one of several clinical-quality molecules inhibiting this receptor
that have been identified by ChemoCentryx.
Peroxisome proliferators exert their effects by activating the peroxisome proliferator-activated receptors
(PPARs), members of the nuclear receptor
Duska is developing Vagonixen(TM) as a blocker of a specific P2 receptor
subtype in the lungs.
Some of these mutations change just a single amino acid within a receptor
protein, so the scientists suspect that they've altered the site on the receptor
where it interacts with the drugs.
The report provides comprehensive information on the KiSS-1 Receptor
(G-Protein Coupled Receptor
54 or G-Protein Coupled Receptor
OT7T175 or hOT7T175 or Hypogonadotropin-1 or Kisspeptins Receptor
or Metastin Receptor
or KISS1R or GPR54), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.