Chronic oral arsenic intoxication as a possible aetiological factor in idiopathic portal hypertension (non-cirrhotic portal fibrosis
) in India.
In the case of Ito cells and bile duct hyperplasia accompanied by portal fibrosis
, we performed the chisquare test within subadult, adult, and old bears to determine age dependency.
In both groups, pericellular/sinusoidal fibrosis had no relationship with portal inflammation (P = .36), ductular reaction (P > .99), portal fibrosis
(P = .30), or steatosis (P = .73).
In that model, we observed that biliary proliferation and portal fibrosis
occurred in both the cholestatic and the unobstructed lobes of the liver in response to biliary obstruction (1).
Various synonyms are used to refer this entity: idiopathic portal hypertension in Japan, non- cirrhotic portal fibrosis
in India, regenerative nodular hyperplasia, benign intrahepatic portal hypertension etc.
Each patients' liver biopsy was done, the details of which are explained elsewhere.14 The fibrosis stage was determined according to a scoring system available in literature, and was classified as F0 = no fibrosis; F1 = portal fibrosis
without septa; F2 = few septa; F3 = numerous septa without cirrhosis; and F4 = cirrhosis.16 The APRI was determined as AST level (UNL)/ platelets counts (109/L) x 100.17 Patients were divided into APRI less than 0.5 to 1 and the other group with APRI greater than 1.
(27) Fibrosis was staged on a scale of 0 to 4: F0 = no fibrosis, F1 = portal fibrosis
without septa, F2 = portal fibrosis
and few septa, F3 = numerous septa without cirrhosis, F4 = cirrhosis.
Biopsy specimens were classified as follows: F0, no fibrosis; F1, portal fibrosis
without septa; F2, few septa; F3, numerous septa without cirrhosis; and F4, cirrhosis.
Liver biopsies performed in four of the six men who met criteria for a biopsy showed either advanced precirrhotic liver fibrosis or moderate hemosiderosis with mild portal fibrosis
In the research into the mechanisms of cholestatic liver diseases, portal fibrosis
seems to be induced by ductular reaction [14, 19, 27, 28].
noncirrhotic portal fibrosis
, congenital hepatic fibrosis, sclerosing cholangitis, schistosomiasis
Early indirect portal changes include mild portal fibrosis
and edema, with a minimal mixed inflammatory cell infiltrate and increased ductular profiles.