These observations suggest that these complexes specifically to target [ER.sup.+] cancer cells such as breast and ovarian cancer cells provide a direct strategy to enhance the antitumor effect of platinum complexes
. In addition, Gou's group  reported conjugation of the Pt(IV) moiety to the ER modulator tamoxifen, named Tam-Pt(IV) (Figure 18(65-68)), which was selectively and efficiently taken up by [ER.sup.+] positive tumor cells.
This research gave way to a new molecular modification method for promoting excimer light emission particular to flat 4-coordinate cyclometalated platinum complexes
, and created platinum complexes
with high color rendering properties despite being a simple light emitting material.
Antitumor platinum complexes
: relationship between chemical properties and activity.
Souza, Novel cyclopalladated and coordination palladium and platinum complexes
derived from [alpha]-diphenyl ethanedione bis (thiosemicarbazones): Structural studies and cytotoxic activity against human A2780 and A2780cisR carcinoma cell lines J.
Karaivanova, "Novel approaches towards development of non-classical platinum-based antineoplastic agents: design of platinum complexes
characterized by an alternative DNA-binding pattern and/or tumor-targeted cytotoxicity," Current Medicinal Chemistry, vol.
Richardson, "Palladium and platinum complexes
with vitamin B6 compounds," Inorganica Chimica Acta, vol.
Key words: triphosphazene, cyclotriphosphazene, platinum complexes
, palladium complexes.