Among alterations observed there was an increase in blood cell volume in secondary lamellae (secondary lamellar dilation), characterizing aneurisms along with smaller and free pillar cells that normally should adhere to pavement cells to form a channel (Fig.
This event is due apparently to a coordinate loss or derangement of junction complexes that connect pillar cells to pavement cells.
By E16.5, Prox1 was expressed in Dieters' cells and pillar cells
of the basal region of the developing cochlea but could not be detected in the apical region.
9B), and many vacuoles also appeared in the cytoplasm of the epithelial and pillar cells
The secondary lamellae showed hypertrophy of the secretory cells, epithelial lifting, alteration of the structure, pyknotic nucleus of the pillar cells
, secretion of mucus in interlamellar space, infiltration of cells of the immune system and fusion and occurrence of aneurysms of various sizes in some secondary lamellae (Figure 4).
No evidence was found for CYP1A expression in the epithelium and vascular endothelium of the gills from the QMH fish; however, pillar cells
in gills from 1 of 11 fish showed slightly positive staining for CYP1A (Figure 3, Table 1).
In the neonatal cochleae of mammals, the Wnt target gene Lgr5 is expressed in a subset of SCs (the pillar cells
, inner phalangeal cells, and Deiters' cells) , and these endogenous Lgr5+ cells maintain mitotic quiescence.
The epithelial lining of the secondary lamellae comprised epithelial pavement cells, few mucous cells and pillar cells
. The pillar cells
interposed the enriched blood capillaries (Fig.
Such salt-transporting gills exhibit a typical microanatomy: the highly flattened, cuticle-bounded gill lamellae essentially consist of a continuous layer of epithelial cells enclosing a narrow hemolymph space; linked pairs of sustaining pillar cells
extend across this space between the opposing epithelial sheets, their apical flanges often forming part of the epithelium (Mantel and Farmer, 1983; Taylor and Taylor, 1986; Maina, 1990).