Figure 2 compares the percutaneous absorption
of zolmitriptan through Strat-M synthetic membrane with that through dermatomed ex vivo human skin over five hours.
Environmental temperature and the percutaneous absorption
of a cholinesterase inhibitor, VX.
The effects of some permeability enhancers on the percutaneous absorption
Analysis of variance (ANOVA) was used to determine significant differences between percutaneous absorption
values obtained from different samples (significant level accepted ?P < 0.01) using the Statgraphics program.
The lag time always played a significant role in the percutaneous absorption
of the drug and was calculated from x- intercept of the slope at the steady state.
Terpenes have been utilized for a number of therapeutic purposes, such as in antispasmodics, carminatives, perfumery, and others, but a few reports also suggest their potential as percutaneous absorption
 studied the effect of vehicles and enhancers on the in vitro and in vivo percutaneous absorption
of MTX through hairless mouse skin.
Studies and reported cases have demonstrated that hydration of the skin increases penetration of certain drugs, including lindane.[2,8,9,11] This results in an elevated systemic absorption probably secondary to increased percutaneous absorption
with heat-associated dermal vasodilatation.
The lipophilic nature of vitamin E makes it suitable for topical application and percutaneous absorption
through the skin.
"Cutaneous Metabolism of Xenobiotics." Percutaneous Absorption
, pp 53-75 (R.L.
What is true for sublingual absorption and the jugular vein could be true for any sampling site located downstream of any other absorption site, such as the human cubital vein after percutaneous absorption
of BPA from thermal receipt paper, leading to serum BPA concentrations > 1 ng/mL (vom Saal FS, personal communication).
Since these products are used for long duration, on a large body surface area and under hot humid conditions, percutaneous absorption
is enhanced .