The barrier function of the skin in relation to percutaneous absorption
In vivo percutaneous absorption
of DEHP from DEHP-piasticized polyvinyl chloride film in male Fischer 344 rats.
theoretical description, J.
Chemical enhancement of percutaneous absorption
in relation to stratum corneum structural alterations.
the leading provider of topical formulation development services for prescription products, will present a new poster - "Characterization of Potential Percutaneous Absorption
and Penetration Differences of Human Dermatomed Skin and Dermis-Only with Various Receptor Phase Flow Rates, In Vitro, using ((3)H)-Clotrimazole and ((3)H)-Hydrocortisone as Model Compounds" at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting in Atlanta, Georgia, November 17th-19th.
Guy's principal scientific achievements are in the areas of characterizing the function of the skin barrier to drug absorption, enhancement of percutaneous absorption
, iontophoresis, noninvasive bio-sensing of blood glucose and other analytes, and the prediction and assessment of skin penetration and topical bioavailability.
of Clindamycin Phosphate from Foam and Gel Vehicles: An In Vitro Human Skin Penetration Study 8.
In the first study, in-vitro measures of percutaneous absorption
demonstrated more than 2 to 3 times more penetration than other formulations with up to 10% BPO.
The researchers concluded that the carrier used in PENNSAID(TM) progressively enhanced percutaneous absorption
of diclofenac over 48 hours when used in a multi-dose regimen as compared with an aqueous control.