Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice
samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms.
Body fluids and excrements such as saliva, urine, stool, or pancreatic juice
can be used to detect PDAC; therefore, it is relevant to consider the role of body fluids in determining biomarkers.
In addition, the testing efficiency of miRNAs that were derived from tissue is higher than that of blood and pancreatic juice
Kim et al., "Evaluation of pancreatic exocrine function using pure pancreatic juice
in noninsulin-dependent diabetes mellitus," Journal of Clinical Gastroenterology, vol.
The biliary duct is a small tube that carries pancreatic juices
into the duodenum.
The alkaline digestive glands pancreas and liver are affected most by changes in the blood pH because they manufacture pancreatic juice
and bile, which are generally highly alkaline solutions.
Effect of secretin on pancreatic juice
proteins in caerulein induced acute pancreatitis in the rat.
Two major mechanisms attempt to explain the pancreatic stone formation observed in AIP: calcification after severe inflammation or tissue necrosis specific to AIP and stasis of pancreatic juice
due to irregular narrowing of the pancreatic duct .
It is well known that the matrix metalloproteinases are key regulators of cell proliferation and migration in human pancreatic cancer cells  and that MMP-9 protein is increased in the pancreatic juice
from patients diagnosed with pancreatic ductal adenocarcinomas .
The use of KRAS mutations for the early detection of pancreatic and colorectal tumors has been explored with fine-needle aspirates, pancreatic juice
, or stool DNA, either alone or in combination with other genetic and epigenetic markers (6-8).
Enzymes in the pancreatic juice
flow into a long pancreatic duct that merges with the common bile duct and opens into the duodenal mucosa.
EUROPAC screening includes serum glucose and the CA 19.9 measurement, CT, EUS and ERCP to analyse p16, K-RAS and p53 oncogenes, in pancreatic juice
. If results are negative, the entire process is repeated every 3 years.