Mudhasani et al., "Dicer inactivation in osteoprogenitor cells
compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse," Developmental Biology, vol.
Desmet et al., "Mechanisms of ectopic bone formation by human osteoprogenitor cells
on CaP biomaterial carriers," Biomaterials, vol.
The third passage cells were induced by lineage-specific induction factor to osteoprogenitor cells
(OC-AD-MSCs) according to ALVES et al.
The ability to form new bone via BMA transplantation has been confirmed in basic experiments  and is thought to depend on mesenchymal stem cells (MSCs) or osteoprogenitor cells
. The bone marrow is a source of MSCs, which have the potential to differentiate into mesenchymal tissues such as bone, cartilage, and fat .
This seems to follow the basic principle of guided bone regeneration where a cell occlusive membrane is used in order to create and seal off a space favorable for the exclusive recruitment and proliferation of osteoprogenitor cells
, while preventing the entry of nonosteogenic cells and ultimately leading to complete bone formation [13,14].
Bone graft also acts as a scaffold for osteoprogenitor cells
that will migrate in it and new bone will form .
Storti et al., "Myeloma cells inhibit non-canonical wnt co-receptor ror2 expression in human bone marrow osteoprogenitor cells
: effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells," Leukemia, vol.
(17,18) The endosteum seems to have a key role in providing osteoprogenitor cells
for spontaneous regeneration of bone from residual walls defects.
[sup],, It has been demonstrated that chitosan can improve the proliferation, the differentiation and the mineralization of osteoprogenitor cells
, osteoblasts as well as new bone formation.
It seems that some factors, including bone morphogenetic protein, platelet-derived growth factor, and transforming growth factor-beta have the ability to be chemotactic for fibroblasts and may have some role in aggregating osteoprogenitor cells
at sites of heterotopic ossification.
Guillemot, Laser-assisted bioprinting for creating on-demand patterns of human osteoprogenitor cells
and nano-hydroxyapatite, Biofabrication, 3, 11-17 (2011).
(5) revealed the osteogenic potential of NPY, showing that osteoblast phenotype markers were significantly enhanced in osteoprogenitor cells
stimulated by NPY, probably due to down-regulation of the Y1 receptor.