These composites are mixed with autologous bone marrow which subsequently provides
osteoprogenitor cells and other growth factors.
In the NHO pathogenesis, it is proposed that non-collagen proteins play a role and that fibroblasts take over the role of
osteoprogenitor cells (15).
* A cohesive consistency when saturated with the patient's bone marrow providing both a continuous scaffold for bone formation and the
osteoprogenitor cells needed to initiate new bone growth.
Effects of Maternal Hypoxia on the Size of Fetal Bone Marrow
Osteoprogenitor Cell Pool.
Bareille et al., "The effect of cyclo-DfKRG peptide immobilization on titanium on the adhesion and differentiation of human
osteoprogenitor cells," Biomaterials, vol.
By exploiting the tendency of hOB-iPSCs to revert back towards
osteoprogenitor cells with high rates of proliferation, without the capacity to form adipocytes, large quantities of osteogenic cells can be produced using master banks of germ-layer specific iPSCs.
Bareille et al., "Effect of HUVEC on human
osteoprogenitor cell differentiation needs heterotypic gap junction communication," The American Journal of Physiology, vol.
PRF membrane helps in wound healing by shielding the surgical site, promoting soft tissue repair, when mixed with bone graft, it may also act as a biological connector, which attracts stem cells, favoring the migration of
osteoprogenitor cells to the center of the graft and provides a neo-angiogenesis.
In the first of these studies, the deletion of Dicer in
osteoprogenitor cells impaired bone formation and caused embryonic lethality, while the other study showed that the ablation of Dicer in mature osteoblasts leads to an increased bone mass phenotype [32].
[beta]-tricalcium phosphate scaffold modified with GO significantly stimulated the proliferation and osteogenic differentiation of human bone marrow stromal
osteoprogenitor cells and, importantly, accelerated new bone formation in vivo [16].
Takahashi, "Number of
osteoprogenitor cells in human bone marrow markedly decreases after skeletal maturation," Journal of Bone and Mineral Metabolism, vol.
Iliac crest autograft was chosen in this case due to its established efficacy in foot and ankle arthrodesis surgery, a higher concentration of
osteoprogenitor cells than grafts from the lower extremity, and relatively low donor-site pain [33-35].