Conclusions and clinical relevance: Twice-daily oral administration
of zonisamide to Hispaniolan Amazon parrots resulted in plasma concentrations known to be therapeutic in dogs without evidence of adverse effects on body weight, attitude, and urofeces or clinically relevant changes to hematologic and biochemical variables.
Blood, muscle and liver samples were collected just before time 0 and 1, 3, 6, 9, 12 and 24 h after glucose oral administration
. At each sampling time, four fish were sampled and individually weighed.
It should be noted that jitteriness/anxiety syndrome may develop rapidly after the initiation of oral administration
of even low-dose sertraline.
of RGE Ameliorates Morphological Damage to Spinal Cord in Rats at 2 Weeks after SCI.
Sperm count: Live sperm count is decreased significantly (P<0.05) compared to control and the number of dead sperms increased although there was no significant change in the total sperm count after twice daily oral administration
of the drug for a period of seven consecutive days[Table 5].
A growing body of literature, based on mouse studies, indicates that oral administration
of probiotic bacteria prior to influenza viral infection results in a protective effect against viral-induced damage.
where [[AUC].sub.p.o.] is oral administration
[[AUC].sub.i.v.]/[DOSE.sub.i.v.] is oral dose, [[AUC].sub.i.v.] is intravenous administration AUC, and [DOSE.sub.i.v.] is intravenous dose.
This effect was better in the vaginal method compared with oral administration
(P = 0.03).
The phase I clinical trial is an open label safety and pharmacokinetic study designed to assess the delivery of prGCD after oral administration
of Oral GCD in 12 Gaucher patients.
Pharmacokinetic, tissue distribution, and excretion studies were also performed after single-dose oral administration
, aiming at understanding the relationships between toxicity potential of LDH nanoparticles and their kinetic behaviors in the body.
The rats were sacrificed after 90min of oral administration
and about 0.50ml of blood was collected from each rat into a vial containing heparin (35 units/ml of blood) solution.
of the Pacific) offer a guide to understanding oral bioavailability, to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate students become familiar with its fundamentals and practices in pharmaceutical research and drug development and solve problems in the development of drugs for oral administration
. In 33 chapters, pharmaceutical researchers from North America, Europe, and Asia explain basic and advanced concepts and various approaches and methods for improving and studying bioavailability.