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More specifically, it seems that all clonal populations--including normal, preneoplastic, and frankly neoplastic cells--contain their own complements of stem cells and nonstem cells.
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state.
Deregulation of adhesion and polarity proteins has been shown to cause misoriented mitotic spindles that could lead to symmetric division in nonstem cells and increased self-renewal (16).

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