The four repressed genes are expressed preferentially in neurons and regulate the synaptic function and the neuronal plasticity, while the overexpressed gene is characteristic for neuroglia cells
, its expression is activated as a response to neuronal damage and facilitates myelinization and regeneration.
rosea Salidroside NPY Salidroside Human neuroglia cell
line T98G HSF1 Salidroside Human neuroglia cell
line T98G Hsp70 Salidroside Human neuroglia cell
line T98G Target molecule Test article Concentration/Dose BNDF Salidroside 20 and 40 mg/kg 12 and 24 mg/kg CREB Salidroside 5 [micro]M 50 and 100 [micro] M CREB tCREB/MITF/ R.
Adaptogens stimulate neuropeptide Y and Hsp72 expression and release in neuroglia cells
. 2012 Feb 1:6:6.
Hypothesis: Analysis of RNA microarray of isolated neuroglia cells
and the comparison the number of genes deregulated by plant extracts and their fixed herbal formulation might be a useful tool/method for assessment of synergistic and antagonistic interactions of herbal extracts in human organism.