The presence of 2 mutations in
neuraminidase from the specimen of patient 3, which contained the highest viral load, might suggest a correlation with the efficiency of infection and replication in the conjunctiva.
Neuraminidase inhibitor resistance in influenza viruses and laboratory testing methods.
Impact of
neuraminidase mutations conferring influenza resistance to
neuraminidase inhibitors in the N1 and N2 genetic backgrounds.
Influenza virus A interacts with their hosts mostly through two critical glycoproteins, hemagglutinin (HA-16) and
neuraminidase (NA-9) subtypes.
In fact, published studies by others have recently reported IAP deficiencies and high
neuraminidase levels in IBD patients."
A great Australian example of this kind of work is the study of a molecule from the virus that causes influenza, called
neuraminidase. In the 1980s and 90s, researchers from the CSIRO, led by Peter Colman, used a synchrotron to perform X-ray crystallographic studies of
neuraminidase to determine its molecular structure [Colman, P.M.
It uses an enzyme,
neuraminidase, to break apart the cell walls so that it can enter.
It meant that GSH levels in saliva and blood were equally reliable diagnostic tests.The
neuraminidase levels obtained were 233.1536.13 (mg/100ml) and 279.1873.75 (mg/100ml) in control and patient groups respectively from blood samples which were significant (pless than 0.05).
The [[beta].sub.2]-transferrin in CSF is desialylated because of the presence of
neuraminidase in the central nervous system.
If started promptly, antiviral medications may reduce complications of acute influenza, but increasing resistance to amantadine and perhaps
neuraminidase inhibitors underscores the need for novel prevention and treatment strategies.
[3-6] In September 2009 Jefferson asked Roche for the unpublished data set that Roche used in an analysis published in 2003, for use the following month to update the Cochrane Collaboration's review on
neuraminidase inhibitors in healthy adults.
Hemagglutinin and
neuraminidase are two key proteins displayed on the surface of the virus particle; they are the H and N used in virus strain names like H1N1.
