Reduced AR in peritubular myoid cells
results in decreased sperm output.
Yet, the peritubular myoid cells
exhibited morphology with a tendency towards reestablishing the elongated nuclear shape (Figs.
(46,47) This, in turn, can alter the paracrine communication between Leydig cells, myoid cells
and Sertoli cells, altering spermatogenesis.
(1) Although it represents the most common testicular sex cord-stromal tumor in infancy, a literature search reveals less than 100 reported cases.1 It has been postulated that JGCT originates from primitive, pluripotential gonadal stromal cells or immature Sertoli and peritubular myoid cells
. (2) Pathologically, the tumor contains mucin-containing follicles lined by granulosa cells which stain positive for inhibin-alpha and negative for alpha fetoprotein.
In mammalian testis Spermatogenesis takes place in the seminiferous tubules which are composed of Sertoli cells (SCs) and maturing germ cells surrounded by one (rodents) or more (large animals) layer(s) of peritubular myoid cells
The indicators for diagnosis of HV-CD on histopathology include lymphoid proliferation, where the follicles are regressed or depleted of germinal center cells and have expanded mantle zones with small lymphocytes arranged concentrically in an "onion-skin" fashion, an interfollicular region variably expanded with prominent hyalinized blood vessels; expanded, often dysplastic, follicular dendritic cell networks; myoid cells
; dendritic reticulum cells; and small, mostly T lymphocytes.29,30
The neoplastic smooth muscle cells were mostly spindle-shaped, although in some areas (less than 5% of the sampled tissue; 20 blocks of tumor taken in all) the myoid cells
were epithelioid-shaped [Figure 4b].
The thymus is an anterior mediastinal lymphoid organ that is mainly composed of epithelial cells in the outer cortex, myoid cells
, and lymphocytes in the germinal center.
AQP0 is found in the epididymis of the stallion but not in the rat, whereas AQP1 is found in the bat and rat myoid cells
surrounding the epididymal tubules of the caput region and endothelial cells of the vascular channels throughout the epididymis, but is not found in the mouse.
This tumor originates from perivascular glomus like myoid cells
although no proof of origin exists.