Langlais et al., "Expression of the cereblon binding protein argonaute 2 plays an important role for multiple
myeloma cell growth and survival," BMC Cancer, vol.
Dendritic cell vaccination, an example of this approach, works by induction of idiotype-specific T- and B-cell response that can stimulate the body's own immune system to fight and eradicate
myeloma cells following administration of idiotype-protein pulsed dendritic cells.
Salmon, "A clinical staging system for multiple myeloma: correlation of measured
myeloma cell mass with presenting clinical features, response to treatment, and survival," Cancer, vol.
Hideshima et al., "Proteasome inhibitor PS-341 inhibits human
myeloma cell growth in vivo and prolongs survival in a murine model," Cancer Research, vol.
Keywords: Enhanced green fluorescent protein, Flow cytometry, Monoclonal antibody,
Myeloma cell lines, Transfection
Targeting p38 MAPK inhibits multiple
myeloma cell growth in the bone marrow milieu.
Inhibition of Aurora A has been shown to induce cell death in preclinical multiple
myeloma cell lines.
DMA(V) exerted differential antiproliferative and cytotoxic activity against leukemia and multiple
myeloma cells, with no significant effect on normal progenitor cells (Duzkale et al.
Thus, an inhibition of osteoblast proliferation by
myeloma cells may not necessarily be accompanied by a simultaneously suppressed matrix mineralization.
Furthermore, most, if not all, human
myeloma cell lines which survive in laboratory cell culture have TP53 deficiency, further suggesting its importance in extramedullary disease.
DARZALEX binds to CD38 and inhibits tumor cell growth causing
myeloma cell death.