Langlais et al., "Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell
growth and survival," BMC Cancer, vol.
Dendritic cell vaccination, an example of this approach, works by induction of idiotype-specific T- and B-cell response that can stimulate the body's own immune system to fight and eradicate myeloma cells
following administration of idiotype-protein pulsed dendritic cells.
Salmon, "A clinical staging system for multiple myeloma: correlation of measured myeloma cell
mass with presenting clinical features, response to treatment, and survival," Cancer, vol.
Hideshima et al., "Proteasome inhibitor PS-341 inhibits human myeloma cell
growth in vivo and prolongs survival in a murine model," Cancer Research, vol.
Keywords: Enhanced green fluorescent protein, Flow cytometry, Monoclonal antibody, Myeloma cell
Targeting p38 MAPK inhibits multiple myeloma cell
growth in the bone marrow milieu.
Inhibition of Aurora A has been shown to induce cell death in preclinical multiple myeloma cell
DMA(V) exerted differential antiproliferative and cytotoxic activity against leukemia and multiple myeloma cells
, with no significant effect on normal progenitor cells (Duzkale et al.
Thus, an inhibition of osteoblast proliferation by myeloma cells
may not necessarily be accompanied by a simultaneously suppressed matrix mineralization.
Furthermore, most, if not all, human myeloma cell
lines which survive in laboratory cell culture have TP53 deficiency, further suggesting its importance in extramedullary disease.
DARZALEX binds to CD38 and inhibits tumor cell growth causing myeloma cell