Furthermore, the muscle and nerve biopsy revealed typical fiber Type II grouping atrophy, significantly decreased myelinated nerve fibers with abundantly thin myelinated fibers
and onion bulbs changes.
Thus, accumulation of DCUN1D2 and NEDD8 were strongly correlated with the diameter of the myelinated fibers
Nerve fiber structure in D-gal-treated mice Myelinated fibers
from the control mice appeared compact and homogeneous with integral sheaths; whereas the fibers from the D-gal-treated mice showed dilatation with irregular contours in which some sheaths displayed obvious splitting and vacancy in some places (Fig.
Indeed, lower endoneural capillary density is associated with decreased myelinated fiber
density in DPN patients, which may impair their sensory and autonomic neuronal functions.
On the contrary, intra1 (red, Figures 5(d), 5(e),and 5(f)), intra2 , and intra fl (data not shown) antibodies recognize exclusively myelinated fibers
in tissue from healthy (insets d1, e1, and f1) and progressive MS donors (Figures 5(d), 5(e), and 5(f)), as it is found with rat tissue (Figures 2 and 3).
The conduction velocity of a myelinated fiber
depends on the complex interactions among the structural features of the axon and its myelin sheath, and on the nature and distribution of the conductance mechanisms of the axon (Waxman, 1980).
Sensory transmission in humans occurs through three primary afferent, nerve fiber types : heavily myelinated mechanical afferent pathways (A Beta fibers) that transmit non-noxious tactile sensations, small-diameter myelinated fibers
(A Delta fibers) that transmit sharp pain, and small diameter unmyelinated fibers (C fibers) that transmit dull aching pain.
More than 25 years ago, I published a hypothesis (8) postulating that the delusions of passivity and external control may be caused by an abnormality in the corpus callosum--the largest white matter bundle in the brain, comprised of approximately 200 million myelinated fibers
connecting homologous regions in the left and right cerebral hemispheres.
Due to the constant pain caused by FM, small, unmyelinated nerve fibers are activated more frequently than the larger myelinated fibers
The evidence suggests that effects of spinal manipulative therapy is primarily neurophysiologic, most likely mediated by intense stimulation of large myelinated fibers
in the capsular and/or periarticular tissues.
An efficient and unbiased stereological method was applied to estimate the white matter volume, the total volume, total length and mean diameter of the myelinated fibers
in the white matter and the total volume of the myelin sheaths in the white matter of rat brain.
He concluded that the forebrain contains an average of 22 billion neurons, 157 trillion synapses, and 84,500 miles of myelinated fibers
. The accepted estimate for the rate of neuronal loss in the neocortex alone (which is 86% of the forebrain) is about 31 million per year during normal aging, he said.