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Microscopically tumor comprises of dense fascicles of spindle shaped cells exhibiting evident nuclear pleomorphism and mitotic figures.
Caption: Figure 2: (a) Cytology of the nodules showing anisokaryosis, hyperchromatic and stippled nuclei, prominent nucleoli, intranuclear inclusions, and pigment laden macrophages (H and E; x 100), (b) histopathology showing pleomorphic tumor cells with pleomorphic round to oval nuclei, prominent eosinophillic nucleoli, multinucleate giant cells with intracytoplasmic melanin pigment and atypical mitotic figures (H&E; X100).
However, that lesion is a high-grade tumor with nuclear pleomorphism and frequent mitotic figures, which is not the case for LGSSNMF.
NUMEROUS KERATIN PEARLS AND FEW MITOTIC FIGURES WITH CELLULAR AND NUCLEAR PLEOMORPHISM AND HYPERCHROMATISM WEREALSO SEEN, ADIAGNOSIS OF WELL-DIFFERENTIATED SQUAMOUS CELL CARCINOMA WAS GIVE (H&E 20X).
The cellular morphology includes nuclear pleomorphism with mitotic figures.
Nuclear/ cytoplasmic ratio was approximately 1:3, and rare mitotic figures were observed.
Cytology was characterized by presence of large number of pleiomorphic fibroblasts with anisocytosis, anisokaryosis, prominent nucleoli and mitotic figures (Fig.
Cells exhibited up to 3x anisokaryosis and anisocytosis, with occasional mitotic figures visible.
They did not demonstrate mitotic figures nor atypia.
It should not reveal atypical nuclei, mitotic figures, or microscopic necrosis [13].
The neoplasm is considered a high-grade malignancy when more than 5 mitotic figures per 10 HPFs are found [6].