(1) The underlying cytogenetics is due to translocation t(11;14)(q13;q21), which eventually results in overexpression of cyclin D1, a cell cycle protein not usually expressed in lymphoid cells
; therefore, disrupting the central cell cycle pathway balance resulting in MCL.
B, Biopsy shows sheets of lymphoid cells
that replaced much of the dermis and are separated from the epidermis by a grenz zone.
The aspirate sample was stained with Papanicolaou stain, and results showed groups of small to medium lymphoid cells
with a background of erythrocytes.
The aspiration revealed hypocellular marrow with 50% of atypical small to medium sized lymphoid cells
. Because of the lack of specific antibodies, bone marrow biopsy was performed and based on immunohistochemical profiles (T lymphocytic cells positive for CD2, CD3, CD5, CD8, granzyme and TIA and negative for hairy cell markers, CD10, MUM 1, bcl 1, CD4 and CD56), the diagnosis of T-LGLL was established.
Immunohistochemistry revealed CD3: positive; CD4: small number of lymphoid cells
positive; CD8: majority of the lymphoid cells
positive; CD20: positive; CD30: negative, this report confirmed the diagnosis of LyP.
When the smears showed a monotonous population of lymphoid cells
with mainly rounded nuclei slightly larger than those of normal small lymphocytes and many mitotic figures were taken as suggestive of non-Hodgkin's lymphoma (NHL).
(d) The neoplastic lymphoid cells
in the coronary artery are positive for CD20 (H&E, x200).
Caption: Figure 4: (a) Lymphoid cells
invading sinusoidal spaces (HE 200x); (b) diffuse lymphoid infiltration (HE 200x); (c) nodular lymphoid aggregate (HE200x); (d) area of steatosis (HE100x).
Caption: Figure 3: Hematoxylin-eosin stain of a section through the center of the nodule (a) shows numerous confluent lymphoid follicles composed of large, reactive lymphocytes with intervening smaller lymphoid cells
. An immunostain for the B cell marker CD20 (b) shows that the follicles are composed of B cells, while the stain for the T cell marker CD3 (c) shows that the mantle zone and interfollicular areas have predominantly T cells, typical of benign lymphoid tissue.
In addition, RA induces the homing of innate immune cells, such as innate lymphoid cells
(ILCs)  besides regulatory and effector T and B cells, to the gut [9-11].
van Ree, "Type 2 innate lymphoid cells
: at the cross-roads in allergic asthma," Seminars in Immunopathology, vol.
BCR-ABL1 positivity in both myeloid and lymphoid cells
, rather than just in the lymphoid component, as it was detected in our case, would support the diagnosis of CML in T-cell blast crisis .