Examples of primary neoplasms include hemangioma, hamartoma, lymphangioma, littoral cell
angioma, hemangioendothelioma, and angiosarcoma.
Normal littoral cells
express CD8 so it can be positive in hemangioma, angiosarcoma, and hamartoma, but the lining cells of LCA do not express CD8.
They include hemangiomas, littoral cell
angiomas, splenic hamartomas (SHs), lymphangiomas, hemangioendotheliomas, angiosarcomas, and Sclerosing Angiomatoid Nodular Transformation (SANT).
Frizzera, "Littoral cell
angioma: a novel splenic vascular lesion demonstrating histiocytic differentiation," American Journal of Surgical Pathology, vol.
(8.) Harmon LR, Cerruto CA, Scheckner A: Littoral cell
angioma: case report and review.
(1) Of the various vascular tumors of the spleen, splenic hamartoma and littoral cell
angioma occur only in the spleen.
Of the 15 cases, infarcted spleen in 6 patients (40%), pseudocyst in 4 patients (26.7%), abscess in 2 patients (13.2%), epithelial cyst in 1 patient (6.7%) and lymphangioma in 1 patient (6.7%) and littoral cell
angioma in 1 patient (6.7%) were diagnosed.