SHEsis, a powerful software platform for analyses of linkage disequilibrium
, haplotype construction, and genetic association at polymorphism loci.
analysis: Linkage disequilibrium
(LD) analysis, defined by the delta coefficient (D'), was estimated in both case and control groups for the 5 SNPs of ER-[beta] rs3020449C/T, rs3020450 G/A, rs1271572G/T in rs1256049G/A and rs4986938G/A.
: The LD between SNP pairs was used to calculate the standardized LD value D'  and [r.sup.2] .
Pairwise comparisons for multiple tests among the polymorphic loci showed significant linkage disequilibrium
between loci (Table 3), while 8 loci showed significant evidence for the presence of null alleles (Cxan2, Cxan5, Cxan6, Cxan10,Cxan13, Cxan16, Cxan27, Cxan28) according to Bonferroni correction (p [less than or equal to] 0.05), which can indicate homozygosis excess.
Significant linkage disequilibrium
was not detected between any pair of loci with a Bonferroni correction for multiple comparisons.
Placental expression of arylamine N-acetyltransferases: evidence for linkage disequilibrium
between NATI* 10 and NAT2*4 alleles of the two human arylamine N-acetyltransferase loci NATI and NAT2.
The results of current study showing 10.3% of BD and 33.3% of AS patients with high ACTH-stimulated 17-OH-P levels warrant further analysis to screen CYP21A2 mutations in linkage disequilibrium
with HLA-B51 and HLA-B27 by genetic methods, to confirm their role in the development of male predominant disorders.
Interestingly, rs46522 was at strong linkage disequilibrium
with rs2291725 in the Chinese Han population, which could be interpreted that the rs2291725 in GIP gene could affect genetic susceptibility to CAD in the population.
In addition, the rs731236 and rs1544410 showed a high linkage disequilibrium
. However, both haplotypes T-C and C-T of rs731236-rs1544410 were not significantly associated with childhood ASD.
Due to the absolute linkage disequilibrium
between rs9263726 and the HLA-B* 58:01 allele found in 27 Japanese patients who suffered from allopurinol-induced SCARs, the rs9263726 has been proposed as a surrogate marker for allopurinol-induced SJS/TEN .
Also, linkage disequilibrium
can imply that variants in genes in close proximity to each other may segregate (travel together) during recombination or random assortment.