mouse

(redirected from knockout mouse)
Also found in: Dictionary, Thesaurus, Medical, Encyclopedia, Wikipedia.
Related to knockout mouse: Gene targeting

mouse

a device used to move a pointer around a COMPUTER screen.
References in periodicals archive ?
Knockout mouse stem cells have only one copy of each gene, whereas a regular cell would have two copies of every gene.
For example, an alcohol researcher interested in gene X could obtain broad-based phenotyping data from the central repository for the knockout mouse generated for gene X, which would provide basic information on many baseline measures.
KOMP2 is part of a global initiative to create a repository of knockout mouse lines and phenotype data which researchers could then use to develop better models of human diseases such as cancer, heart disease, neurological disorders, diabetes and obesity.
A nonhuman animal model such as a DOCK2 knockout mouse, in which the function to control lymphocyte migration has been deleted or suppressed, is generated by deleting DOCK2 gene on the chromosome.
Comparisons of the knockout mouse liver tumor expression profiles with those induced by ciprofibrate or diethylnitrosamine showed that these mice shared a number of deregulated (up-or down-regulated) genes with ciprofibrate-induced liver tumors.
Hannon explains that creating a knockout mouse can take well over a year, while knocking down a gene with RNAi takes only a few days.
Other neurologic functions--such as motor coordination, feeding, and locomotor activity--do not appear altered in the knockout mouse.
Several relevant receptor subunit knockout mouse lines have been used in alcohol research to evaluate contributions of a specific receptor subunit in alcohol's behavioral actions, such as sedation, initial sensitivity, ataxia, withdrawal, tolerance, or consumption.
is a provider of drug discovery tools to the biopharmaceutical industry, and offers access to its inventory of knockout mouse lines and related phenotypic data to enhance the efficiency of target validation and drug discovery.
Researchers utilised the glucose-6-phosphatase knockout mouse model, which is intended to replicate the impairment of this enzyme's activity in patients with GSD Ia.
The IMPC is an international scientific attempt to create and characterize the phenotype of 20,000 knockout mouse strains.
Table 1 Examples of Knockout Mouse Studies Conducted Between 2007 and 2011 That Demonstrate the Effects of the Deletion of Various Genes on Ethanol Consumption Knocked-out Gene Result * Reference CB1 receptor [down arrow] drinking Vinod et al.