The patient had clinical features of Emery-Dreifuss muscular dystrophy: prominent joint contractures
of his elbows, neck, and ankles, as well as a scapula-peroneal distribution of muscle weakness.
Due to his age, symptoms, and significant IP joint contracture
, surgical release of both A1 pulleys was indicated.
One achieved union, however experienced persistent wound drainage and significant joint contractures
, which led to a poor functional outcome.
The study demonstrated that two concurrent injections of XIAFLEX in patients with multiple Dupuytren's contractures resulted in comparable improvement in joint contracture
and range of motion to those seen in previous studies when XIAFLEX was administered as single injections, 30 days apart.
Specifically, for this post hoc analysis, the definition of recurrence was (a) a joint contracture
that was successfully treated (had previously achieved a reduction in contracture to five degrees or less at the Day 30 evaluation after the last injection of XIAFLEX) that subsequently increased by at least 30 degrees compared with the reference value or, (b) a joint which underwent correction to treat contracture in that joint.
Marie Badalamente of the State University of New York at Stony Brook reported on the long-term efficacy and tolerability of XIAFLEX in patients with joint contracture
of at least 20 degrees.
Marie Badalamente of the State University of New York at Stony Brook, reported on the long-term efficacy and tolerability of XIAFLEX in patients with joint contracture
of 20o or greater.
As previously reported, data from the double-blind phase showed that injecting the collagenase enzyme into study patients' affected joints led to a 91 percent success rate in reducing joint contracture
to within five degrees of normal, compared to the placebo arm in which no patients achieved success.
Each of the CORD I and II trials successfully met the primary endpoint, a reduction in the angle of a patient's joint contracture
to </= 5 degrees of normal, as measured by digital goniometry, 30 days after the last injection.