Dendrimers to Enhance Water-solubility of Antipsychotic Drugs for Intranasal Administration
Objective: To compare sedation in cockatiels (Nymphicus hollandicus) after intranasal administration
of midazolam and midazolam-butorphanol.
Assessment of nasal symptoms of AR was performed on the 17th day of the experiment after the 3rd intranasal administration
of the OVA solution.
For intranasal administration
group, six rats were anesthetized with 5% chloral hydrate (250 mg/kg, i.p.).
of crushed Morphine ARER was associated with a 49% and 68% reduction in [C.sub.max] for morphine and M6G, respectively, and a 75% and 68% reduction in [AUC.sub.0-0.5] for morphine and M6G, respectively, compared with crushed intranasal ER morphine.
Hallschmid, "Intranasal administration
of insulin to the brain impacts cognitive function and peripheral metabolism," Diabetes, Obesity & Metabolism, vol.
Royce et al., "Intranasal administration
of mesenchymoangioblast-derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease," The FASEB Journal, 2017; fj.201700178R DOI: 10.1096/fj.201700178R
Lately, there is an increased awareness in the literature regarding the relevance of intranasal administration
of oxytocin in most of the neuropsychiatric disorders, and especially in those related to social behaviour, such as autism, anxiety, depression, social cognition in schizophrenia, in Prader Willi syndrome etc.
Following intranasal administration
, 1 [micro]g/kg has an onset time of 45 minutes with a peak effect at 60-105 minutes in healthy adults.
Compared with control rats or SE rats 24 hrs following Pc, we found that intranasal Ptx pretreatment to SE rats significantly increased the levels of Nrf2, followed by upregulation of HO-1 and NQO-1 at mRNA and protein levels in Ptx-pretreated SE rats, which suggested that intranasal administration
of Ptx might increase the antioxidative capability of cells by enhancing the SE-induced transient activation of Nrf2.
The findings of the comparison study between surgical and intranasal administration
reveals that the non invasive method (intranasal) is more effective (Burbidge et al.,1997).
Following the manufacturer's instructions, 20 nmol of miR-146a mimics (Catalog number: M02010; Genesky Biotech, Shanghai, China) was dissolved in 1 mL RNase-free water and then stored at -20[degrees] C before intranasal administration
for the subsequent experiments.