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Similarly, a sneeze may precipitate disc prolapse by squeezing effect on the intervertebral disc. In this study 6.5% (n=12) of patients suffered disc prolapse from sneezing.
Vertebral Endplate Defect as Initiating Factor in Intervertebral Disc Degeneration: Strong Association Between Endplate Defect and Disc Degeneration in the General Population.
Moreover, the research team plans to test out eDAPS in models of human intervertebral disc degeneration, thus hopefully getting one step closer to clinical trials.
This retrospective study included a total of 2,340 thoracic intervertebral disc levels in 195 patients in whom MRI examination was performed for the complaint of dorsalgia.
All consecutive patients meeting the inclusion criteria with diagnosis of DLSD including lumbar prolapsed intervertebral disc (PIVD) and lumbar spinal stenosis and having baseline pain grade of moderate or severe on visual analogue scale (VAS) were enrolled in the study through outpatient department and were admitted to neurosurgery ward for further work up.
Key words: Cancellous bone, injury, intervertebral disc, inflammation, osteocytes, vertebra.
A possible explanation of this phenomenon is that moderate compression may increase the cell viability, but this improvement cannot contribute to the stemness ability of intervertebral disc stem cells (Figure 2, values are presented as means [+ or -] SD, *p < 0.05 and **p < 0.01 versus control).
A recent study confirmed that compressive stress caused the change of cytoskeletal structure, function, and extracellular inflammatory mediators of nucleus pulposus through the changes in fluid shear stress inside the nucleus pulposus, thereby leading to intervertebral disc degeneration [8].
MRI of L4-L5 showed a degenerative change of intervertebral disc, severe bilateral foraminal stenosis, and moderate central stenosis.
It is widely accepted that magnetic resonance imaging (MRI) has thus become the dominant imaging modality for the evaluation of intervertebral disc degeneration (IDD).[1],[2] Disc matrix which consists primarily of aggrecan and Type II collagen is the primary component of the intervertebral disc.

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