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* A review of the Intermittent Claudication products under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Our goal was to identify the causative disease of intermittent claudication. As described previously, the candidate diseases are PAD and 2 varieties of LSS, L5 and L4.
In the Framingham study 20% of the men and women with intermittent claudication had diabetes compared with 6 persons of those without intermittent claudication.
Exercise is the most consistently effective treatment for intermittent claudication, as is proven by a number of studies.
Hypertension increases the risk of intermittent claudication 2.5- to 4-fold in men and women, respectively, and the risk is proportional to the severity of hypertension (11).
Cessation of smoking in patients with intermittent claudication; effect on the risk of peripheral vascular complication , myocardial infarction and mortality.
(2,4,6,11,13-16,18,32) In humans, intermittent claudication (IC) is an exercise-induced, pathognomonic symptom of peripheral arterial disease involving the legs.
Chief symptoms were intermittent claudication, rest pain, gangrene of toes and ulceration at tip of toes or foot (Table 2).
In a study published in the Journal of the American Geriatrics Society, researchers set out to determine whether asymptomatic lower extremity peripheral arterial disease (PAD) and leg symptoms other than intermittent claudication (IC) in PAD are associated with taster functional decline than in people with both PAD and IC.
When a resting ABI is normal in patients with symptoms of intermittent claudication, exercise testing is recommended to enhance the sensitivity for detection of LEAD (Stein, et al., 2006) The majority of patients with claudication have ABI readings ranging from 0 3 to 0.9 Rest pain or severe occlusive disease typically occurs with an ABI < 0.50.
Anatomically the persistent sciatic artery is the continuation of internal iliac arteries and usually leads to several symptoms such as intermittent claudication, pulsatile mass in the buttocks, and pain radiating to the lower limb.

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