According to the researchers, these findings, coupled with results from previous studies, suggest that treating certain HIV-infected people with a combination of antiretrovirals and an immunotoxin
might help achieve sustained disease remission, in which HIV can be controlled or eliminated without a lifetime of antiretroviral therapy.
Recombinant anti-CD25 immunotoxin
RFT5(SCFV)-ETA' demonstrates successful elimination of disseminated human Hodgkin lymphoma in SCID mice.
are drugs created by linking an antibody to a portion of bacterial or plant toxin to destroy cells expressing the molecule to which the antibody binds.
have lived up to their billing as cancer killers, but they also trigger changes in cells lining blood vessels.
In 2004, the company decided to focus its therapeutic activities on oncology and in December of that year in-licensed two anti-CD22 immunotoxin
programs from the National Cancer Institute (NCI) -- GCR-3888 and GCR-8015.
In animal experiments, Roth has successfully treated metastases(cancer spread beyond the initial site) using an immunotoxin
made from a monoclonal antibody against the tumor, and with a plant product called ricin, which inhibits protein synthesis; one molecule of ricin can kill a cancer cell.
Complete remissions in 3 of 12 patients with chemotherapy-refractory pediatric acute lymphoblastic leukemia (ALL) during phase I testing of the anti-CD22 immunotoxin
moxetumomab pasudotox (CAT-8015)- presented by Dr.
The in vitro cytotoxicity of Rap-hRS7 on Calu-3 human lung and PC-3 human prostate cancers was 50- and 30-fold higher than free RNase, and 10- to 20- fold more potent than an irrelevant immunotoxin
The terms of the agreement call for Millennium and BZL to jointly develop the immunotoxin
and radiolabeled products for the prostate cancer indication until a predetermined clinical decision point.
CAT-5001 is an immunotoxin
fusion protein between a murine anti-mesothelin dsFv and the Pseudomonas exotoxin PE38.
therapy is a promising molecular cancer treatment strategy.
Properties of New Immunotoxin
Described in Blood Article -