can be managed by conservative and symptomatic treatment such as low calcium and vitamin D formula, intravenous hydration, and loop diuretics.
Bone invasion of tumor cells: The most common cause of hypercalcemia
is bone destruction due to osteoclasts activated by tumor cells which metastasize to the bone.
Non-Hodgkin's lymphoma presenting as multiple bo- ne lesions and hypercalcemia
. Am J Hematol.
Familial benign hypocalciuric hypercalcemia
and neonatal primary hyperparathyroidism.
However, pediatricians are also encountering children with mild-to-severe consequences of vitamin D intoxication, often associated with hypercalcemia
. Vitamin D intoxication is generally defined as serum levels of 25-hydroxyvitamin D [25(OH)D] above 100-150 ng/mL (250-375 nmol/L) (1,3,4,5).
The successful management of hypercalcemia
usually depends on determining its etiology.
Clinically, our patient also demonstrated most of the classic signs/symptoms of multiple myeloma, with the exception of hypercalcemia
. Diagnosis was eventually confirmed with core needle biopsy.
can be a problem, both acutely and in the resolving phase, and algorithms for evaluation and follow-up may be useful (Pediatr Dermatol.
is also associated with other pathologies, our findings demonstrate that it is possible to detect hypercalcemia
associated with cancer in murine models using this cell-based diagnostic strategy," the authors write.
is reported in 10% to 20% of patients with sarcoidosis and is generally asymptomatic.
If you don't have any of these illnesses or symptoms of hypercalcemia
, talk to your doctor to make sure they haven't overlooked something.
Laboratory investigations revealed hypercalcemia
(3.1 mmol/L), hypophosphatemia (0.55 mmol/L), and elevated intact PTH level (1028.9 pmol/L).