At 1000X inflammatory patches were observed and almost completely lost hepatic cell
In the antiviral treatment of CHB, IFN-a can inhibit virus replication and degenerate virus mRNA, which can lead to the decline of serum HBV-DNA load, HBsAg levels, and HBeAg content, also it can stimulate the HBV specific or nonspecific immune response to clear the infected hepatic cells
expressed as ALT elevation and decrease of virus and antigens levels.
Our current findings revealed that stem cells, which are expected to be responsible for the repair of the damaged hepatic cells
, were increased in rats with cholestasis, whereas this increase was modulated by either UDCA, MT, or combined treatment.
It was also aimed to review the terminology and definition of hepatic cells
, which are controversial in the literature.
We thus speculate in line with previous findings in hepatic cells
 that the GPX4-dependent death signaling, in which 12/15-LOX is still considered to represent one of the key enzymes leading towards cell death, does play a major role in hepatic IRI.
The UA-micro-treated animals (2000 mg/kg p.o.) showed plates of hepatic cells
and sinusoids but preserved hepatocytes nuclei (Figure 2(b)).
The hepatic cells
were localized radially and intact large spheric nuclei and granular cytoplasms were observed (Figure 4).
According to the pathogenetic mechanism of hepatic fibrosis, the inhibition of hepatic fibrosis is mainly achieved through three pathways: inhibition or reduction of the damaging effects of harmful factors on hepatic cells
; regulation of the expression of cytokines and related signaling proteins, inhibition of the activation of the immune cells or stellate cells, or promotion of apoptosis; and inhibition of collagen hyperplasia or enhancement of collagen degradation.
of liver of group I albino rat (control group) showing central vein (a), Hepatic sinusoids (b), Plates of hepatic cells
Lesions or destruction of hepatic cells
releases these aminotransferases into the circulation .
Studies show that NAC increases the glutathione and antioxidant pools in hepatic cells
and thus increases the resistance of hepatic cell