Sensorineural hearing loss is the result of damage to and/or loss of sensory hair cells
in the inner ear.
To figure out how exactly Activin A and follistatin coordinate hair cell
development, the researchers studied the effects of each of the two proteins individually.
Release date- 05082019 - Using genetic tools in mice, researchers at Johns Hopkins Medicine say they have identified a pair of proteins that precisely control when sound-detecting cells, known as hair cells
, are born in the mammalian inner ear.
dysfunction can result in many types of hearing and balance problems.
Brennan et al., "Wnt signaling mediates reorientation of outer hair cell
stereociliary bundles in the mammalian cochlea," Development, vol.
General cell morphology, corti organ surface anatomy, and outer hair cell
stereocilium structure were evaluated through SEM.
Sensory neural hearing loss (SNHL) is one of the most disabilities in the world that mainly results from dysfunction of mechanosensory hair cells
of the cochlea (Okano & Kelley, 2012).
Vasoconstriction in cochlea has been reported as an important contributor to hair cell
damage, and emerging evidence suggested that inflammatory genes including TNF[alpha] reduced systemic and/or regional blood flow in inner ear, leading to NIHL .
Micro-mechanics and Otoacoustic Emissions.
Transplanted cells co-expressing myosin VIIa and [beta]-gal were considered as "hair cell
The total number of possible hair cell
bundles (the sum of those intact, damaged, and missing labeling) in each image was tested for normality and homogeneity of variance using Bartlett and Shapiro tests, respectively, and then tested for differences between conditions with a one-way analysis of variance (ANOVA).
Combining this new knowledge about Lgr5-expressing cells with the previous finding that Notch inhibition can regenerate hair cells
will allow the scientists to design new hair cell
regeneration strategies to treat hearing loss and deafness.