Sensorineural hearing loss is the result of damage to and/or loss of sensory
hair cells in the inner ear.
To figure out how exactly Activin A and follistatin coordinate
hair cell development, the researchers studied the effects of each of the two proteins individually.
Release date- 05082019 - Using genetic tools in mice, researchers at Johns Hopkins Medicine say they have identified a pair of proteins that precisely control when sound-detecting cells, known as
hair cells, are born in the mammalian inner ear.
Hair cell dysfunction can result in many types of hearing and balance problems.
Brennan et al., "Wnt signaling mediates reorientation of outer
hair cell stereociliary bundles in the mammalian cochlea," Development, vol.
General cell morphology, corti organ surface anatomy, and outer
hair cell stereocilium structure were evaluated through SEM.
Sensory neural hearing loss (SNHL) is one of the most disabilities in the world that mainly results from dysfunction of mechanosensory
hair cells of the cochlea (Okano & Kelley, 2012).
Vasoconstriction in cochlea has been reported as an important contributor to
hair cell damage, and emerging evidence suggested that inflammatory genes including TNF[alpha] reduced systemic and/or regional blood flow in inner ear, leading to NIHL [3].
Hair Cell Micro-mechanics and Otoacoustic Emissions.
Transplanted cells co-expressing myosin VIIa and [beta]-gal were considered as "
hair cell like" (22).
The total number of possible
hair cell bundles (the sum of those intact, damaged, and missing labeling) in each image was tested for normality and homogeneity of variance using Bartlett and Shapiro tests, respectively, and then tested for differences between conditions with a one-way analysis of variance (ANOVA).
Combining this new knowledge about Lgr5-expressing cells with the previous finding that Notch inhibition can regenerate
hair cells will allow the scientists to design new
hair cell regeneration strategies to treat hearing loss and deafness.