Third, the patients with HD in this study were heterogeneous mix regarding severity that would interfere with the power of genetic association
studies. Subgroups of HD with severity profile may be more suitable in future research.
Comparisons between immune non-response and immune response groups were performed through Fisher's exact test or Chi-square test for categorical variables (sex, ART regimens, genetic association
tests) and Mann-Whitney test for continuous variables (age and pre-ART CD4+ T cell absolute counts).
In a GWAS and in multi-staged replication studies carried out in a Japanese population, a new genetic association
between AFF1 rs340630 polymorphism and genetic predisposition to SLE with genome-wide significance level was identified (11).
Furthermore, genetic association
studies provide useful information that could potentially reduce the burden of disease in three main ways.
between common beta-2 adrenoreceptor polymorphism and asthma severity in school-age children.
As lactase persistence is a dominantly inherited genetic trait, we examined the genetic association
primarily under a dominant model (CC vs CT + TT).
studies have been conducted to evaluate the association between genetic polymorphisms and different AP phenotypes, and thus determine whether genetic polymorphisms are associated with AP.
Abbott, "A principal components regression approach to multilocus genetic association
studies," Genetic Epidemiology, vol.
Numerous evaluations of genetic association
have also led to the remarkable potential for the discovery of novel genetic biomarkers.
studies have been increasingly used in cattle breeding programs.
Researchers combined different types of genetic association
analysis to identify 14 genes across the genome that were involved in the synthesis of vitamin E.
Since ethnic variation in allele frequency is widely documented, [3,8] population specific data of VDR polymorphism has to be generated before conducting a valid genetic association