The organization of adherens junctions and desmosomes at the cardiac intercalated disc is independent of gap junctions
proteins and represent a protein family with high homology
When studied via gap junctions
, lactate is more rapidly discharged from cancer cells than protons, which are highly-buffered by a variety of intracellular bases .
Capitanio, "Subcytotoxic mercury chloride inhibits gap junction
intercellular communication by a redox- and phosphorylation-mediated mechanism," Free Radical Biology & Medicine, vol.
Many studies have revealed that myocytes and fibroblasts are functionally coupled by gap junctions
when fibrosis occurred and may interact and modify impulse conduction via two-way electronic signal [8-10].
Johnson, "Inhibition of gap junction
and adherens junction assembly by connexin and A-CAM antibodies," The Journal of Cell Biology, vol.
Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction
X-linked Charcot-Marie-Tooth type 1 (CMT1X) disease is a hereditary chronic progressive disease, which is caused by mutations in the gap junction
beta-1 protein ( GJB1 ) gene encoding the gap junction
protein connexin 32 (Cx32).
Diverse gap junctions
are found between various retinal neurons, (40,41) and electrical transmission through gap junctions
serves various lateral interactions.
ECM-receptor interaction, fatty acid metabolism, TGF-beta signaling, and gap junction
pathway were involved in these predicted pathways.
GJB4 and GJB6 code for gap junction
proteins connexin 30.3 and connexin 30, respectively.
The gap junctions
(GJs) are hemichannels, called connexons, each formed by six connexins.